Samuels was born in Los Angeles, California in April of 1994. She is the daughter of Kathy and Scott Samuels, a producer for unscripted television series and a U.S. marshal. She has three brothers, Cody, Harrison, and Jack, and one sister, Heather.
She made her television debut on the Nickelodeon comedy Drake & Josh as Ashley Blake, though it was a minor role that lasted all of one episode. Since then Samuels has landed several larger role, starting with her main role as Andi Bates in the ABC supernatural drama The Gates. Following that was main and recurring roles on The Nine Lives of Chloe King, American Horror Story, Scream Queens. After landing her role on Scream Queens, she was forced to take a quarter off from Stanford University, where she studied Marketing and Intellectual Property.
- She graduated from Stanford University in June 2016.
- Initially cast in a guest starring role, Samuels was promoted to a series regular for the second season.